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pentobarbital will minimize the level or effect of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/keep an eye on. Barbiturates can induce hepatic microsomal enzymes resulting in greater metabolism and lessened anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon